Abstract
Eleven subjects who had previously been shown to develop a high level of immuno-reactive
insulin after a diet high in sucrose were again put on to this diet for 4 weeks. After
2 weeks, some of the subjects were given phenformin, and the remainder given placebo
tablets; a week later, the treatments were reversed. As we had found previously, the
high sucrose diet produced an increase in body weight in these subjects, raised the
level of plasma triglyceride and cholesterol, and increased platelet adhesiveness.
It had no effect on clot lysis but appeared to reduce the content of plasma fibrinogen.
In addition, there was an increase in the level of immuno-reactive insulin in fasting
plasma of about 30% and a much greater increase of 300% or 400% in the level of 11-OHcs
in fasting plasma. Phenformin restored all these changed values towards normal. It
also reduced clot lysis time and the level of plasma fibrinogen.
Key words
Immuno Reactive Insulin - Sucrose Diet - Phenformin - 11-Hydroxycorticosteroids
